A new vaccine has been announced that has shown to be effective in reversing the effects of type 1 diabetes better than any other drug that has been on the market for a significant amount of years.
1.25 million people in the United States suffer fro type 1 diabetes, and while there are drugs available to treat the symptoms of the disease, until now there has been no way to reverse the effects.
The new vaccine was actually used over 100 years ago to treat tuberculosis, and is used currently to treat bladder cancer, and is considered a safe drug.
The announcement was made at the 75th Scientific Sessions of the American Diabetes Association, stating that the FDA will test the vaccine on 150 people who are in an advanced stage of type one diabetes.
Type 1 diabetes occurs when a person is unable to produce insulin because of a problem with their immune system.
The body produces T cells which affect the pancreatic islets interfering with insulin production, but the new drug works by killing the T cells. The new vaccine increases the levels of a substance called tumor necrosis factor (TNF) which destroys the T cells.
A previous trial has shown that patients injected twice withing 4 weeks had depleted T cells, and some had even started producing their own insulin
Dr. Denise Faustman, director of the Massachusetts General Hospital Immunobiology Laboratory in Boston has said about the vaccine:
In the phase I (preliminary) trial we demonstrated a statistically significant response to BCG, but our goal in (this trial) is to create a lasting therapeutic response. We will be working again with people who have had type 1 diabetes for many years. This is not a prevention trial; instead, we are trying to create a regimen that will treat even advanced disease.